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Synthesis of Novel Pyrimido[4,5-c]pyridazines and 1,2-Dihydro-3a,7,9,9b-tetraaza-cyclopenta[a]naphthalen-3-ones as Potent Inhibitors of Lymphocyte Specific Kinase (LCK).

✍ Scribed by John C. VanRens; Mark Sabat; Todd A. Brugel; Jennifer Maier; Matthew J. Laufersweiler; Adam Golebiowski; Steve Berberich; Biswanath De

Publisher: John Wiley and Sons
Year: 2007
Weight: 34 KB
Volume: 38
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200706150

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## Abstract Efficient and direct protocols for the regioselective synthesis of the title compounds (IV) and (IX), resp., using multicomponent reactions of 5‐aminouracil (II) are given.