A novel prostaglandin analogue, n-heptyl-4-(3-hydroxy-trans-1-octenyl)-1,3-thiazolidin-2-thione, containing heteroatoms in the ring has been synthesized. The key step in the synthesis was the preparation of the five-membered ring starting from of L-cysteine ethyl ester hydrochloride.
Synthesis of novel prostaglandins containing a boronate in the α chain
✍ Scribed by Zixia Feng; Mark Hellberg
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 132 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A novel class of prostaglandins containing a boronate in the a chain have been synthesized. The key steps in the synthesis were the preparation of the ylide containing the boronate and the subsequent Wittig reaction using the ylide.
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