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Synthesis of Novel Iminosugar-Based Trehalase Inhibitors by Cross-Metathesis Reactions

✍ Scribed by Davide Bini; Matilde Forcella; Laura Cipolla; Paola Fusi; Camilla Matassini; Francesca Cardona

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
693 KB
Volume
2011
Category
Article
ISSN
1434-193X

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✦ Synopsis

The synthesis of a novel class of trehalase inhibitors composed of iminopyranose or iminofuranose residues linked at the pseudoanomeric carbon through an alkyl chain is described. A set of six novel compounds was prepared by the same reaction sequence involving the Grubbs Ru-carbenecatalyzed cross-metathesis (CM) of different N-Cbz-pro-[a

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