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Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents

โœ Scribed by F. F. Abdel-Latif; E. Kh. Ahmed; R. Mekheimer; M. M. Mashaly


Book ID
105671648
Publisher
Springer
Year
1997
Tongue
English
Weight
212 KB
Volume
20
Category
Article
ISSN
0253-6269

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Synthesis and biological evaluation of 3
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Fourteen new 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives were synthesized. Six compounds displayed potent inhibitory activities against COX-1/2 and 5-LOX with IC 50 in the range of 0.10-9.87 lM. Particularly, 10f exhibited well balanced inhibitory action on these enzymes (I