Synthesis of novel functionalized 4-aza-2,3-didehydropodophyllotoxin derivatives with potential antitumor activity

✍ Scribed by Ajay Kumar; Antonio E. Alegria

• Book ID: 102344078
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 272 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.467

✦ Synopsis

Abstract

magnified image Novel arylamino alcohols were synthesized and these alcohols were used to prepare 12 novel N‐(2‐hydroxy‐ethyl)‐2,3‐didehydroazapodophyllotoxins, in one step, by simple reflux in ethanol. Isolated yields in the range of 50–70% were obtained. J. Heterocyclic Chem., (2010).