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Synthesis of novel ellipticine analogues and their inhibition of Moloney leukaemia reverse transcriptase

✍ Scribed by Géza Timári; Tibor Soós; György Hajós; András Messmer; János Nacsa; József Molnár

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
305 KB
Volume
6
Category
Article
ISSN
0960-894X

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✦ Synopsis

Two new ellipticine analogues were synthetized as potential non nucleoside inhibitors of reverse transcriptase and were tested on Moloney leukaemia virus reverse transcriptase in vitro. Both derivatives (9a,b) showed considerable inhibitory effect; IDs0 was found to be in the range of 2.8 to 4.5 x 10SM.

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