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Synthesis of novel chiral macrolides and their antifungal activity

✍ Scribed by Ming Zhang Gao; Jian Gao; Zun Le Xu; Ralph A. Zingaro

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 91 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00900-0

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✦ Synopsis

Nineteen chiral macrocyclic diamide-diester ligands were synthesized using a three step reaction. The synthesis utilized the condensation of dicarbonyl dichlorides with chiral 2-aminoethanol derivatives. The reaction was catalyzed in a dual catalyst system. Some of the compounds were found to display antifungal activity.

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