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Synthesis of Novel Chiral Ligands from Amino Acids by the Ugi Reaction.

✍ Scribed by Gerald Dyker; Klaus Breitenstein; Gerald Henkel


Publisher
John Wiley and Sons
Year
2003
Weight
121 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract L‐Amino acids (L‐Ala, L‐Phe, L‐Val, L‐Pro) were used as a source of chirality in the diastereoselective synthesis of tetrahydroisoquinoline derivatives. The key step was the Pictetβˆ’Spengler condensation of ketoamides **4** and **10**, which proceeded under very mild conditions. L‐Ala, L