✦ LIBER ✦

Synthesis of Novel Biomimetic Zwitterionic Phosphorylcholine-Bound Chitosan Derivative

✍ Scribed by Rong Zeng; Hua Fu; Yufen Zhao

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 223 KB
Volume: 27
Category: Article
ISSN: 1022-1336
DOI: 10.1002/marc.200500876

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✦ Synopsis

Abstract

Summary: Water‐soluble biomimetic chitosan derivative conjugating zwitterionic phosphorylcholine was efficiently prepared through Atherton‐Todd reaction under the mild conditions, and the possible formation mechanism of zwitterionic product was related to the nucleophilic attack of adjacent 3‐hydroxyl on the D‐glucosamine residue to phosphorus with the help of base. UV absorption and melting behaviors of DNA/phosphorylcholine‐bound chitosan derivative showed that the phosphorylcholine‐bound chitosan derivative could be a new carrier for long‐circulating macromolecular drug delivery.

Structure of zwitterionic PC‐chitosan.

magnified imageStructure of zwitterionic PC‐chitosan.

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