Synthesis of novel aminomethylenebisphosphonates and bisphosphonic acids, containing adamantyl fragment

✍ Scribed by Lidiya I. Minaeva; Ludmila S. Patrikeeva; Maria M. Kabachnik; Irina P. Beletskaya; Boris S. Orlinson; Ivan A. Novakov

• Book ID: 102233801
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 81 KB
• Volume: 22
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.20656

✦ Synopsis

Abstract

Novel aminomethylenebisphosphonates containing an adamantyl fragment were synthesized by a solvent‐free, microwave‐assisted, three‐component reaction of amines, triethyl orthoformate, and O,O‐diethyl phosphite. Several bisphophonic acids were prepared from aminomethylenebisphosphonates by the treatment with trimethylsilyl bromide followed by methanolysis. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 22:55–58, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20656