Synthesis of Novel 5′-Hydrogenphosphonothioate Derivatives of AZT, d4T and ddI.
✍ Scribed by Ying Jin; Ming Sun; Hua Fu; Yu-Fen Zhao
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 128 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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The synthesis, in vitro anti-HIV activity and stability studies of the 5Ј-fluorophosphate derivative of 3Ј-azido-3Ј-deoxythymidine (AZT) are reported. The results support the hypothesis that this phosphorylated entity exerts its biological effect via the delivery of the corresponding 5Ј-mononucleoti