Synthesis of novel 4-(1-ethoxycarbonyl-methylidene)-azetidin-2-ones via a Lewis acid-catalyzed reaction of ethyl diazoacetate
โ Scribed by Gianfranco Cainelli; Paola Galletti; Massimo Gazzano; Daria Giacomini; Arianna Quintavalla
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 127 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
## Abstract We report the synthesis of a class of 4โ(2โoxoethylidene)azetidinโ2โones by a novel Lewis acid mediated reaction of acyldiazo compounds with 4โacetoxyazetidinโ2โones. Using this approach, Cโ3โand Cโ4โsubstituted 4โalkylideneazetidinโ2โones were obtained depending on the choice of starti
Ethyl diazoacetate reacts with a variety of aldehydes in the presence of a Lewis acid catalyst to give either [~-keto esters or a-formyl esters, the types of products mainly depending upon the nature of Lewis acid catalysts employed. Reactions catalyzed by Lewis acids such as SnCI2 and SnCl4 provide