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Synthesis of Novel [1,2,4]Triazolo[3,4-d][1,5] Benzodiazepinones Derivatives by 1,3-Dipolar Cycloaddition
✍ Scribed by Aatif, A.; Baouid, A.; Benharref, A.; Hasnaoui, A.
- Book ID
- 121445235
- Publisher
- Taylor and Francis Group
- Year
- 2000
- Tongue
- English
- Weight
- 375 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0039-7911
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## Abstract The reaction of N‐aryl‐C‐ethoxycarbonyl nitrilimines with [1,2,4]triazepin‐3,5‐dithione leads to title compounds. The 1,3‐dipolar cycloaddition is completely peri and regioselective. The preferred orientation of addition is predicted correctly by AM~1~ calculation.
## Abstract Reaction of 1,5‐benzothiazepines **3**, obtained from chalcones **2** and __o__‐aminobenzenthiol, with the (phenylhydrazino) chloromethylenecarboxylates **4** in the presence of Et~3~N leads to a series of new [1,2,4]triazolo[5,4‐__d__][1,5]benzothiazepine derivatives **5**. Their struc
## Abstract New tricyclic 1,2,3‐triazolo‐1,2,4‐triazolo‐pyridazine derivatives, bearing a methyl substituent on the 1,2,3‐triazole ring, were prepared as potential biological agents. __N__‐Methylation of dimethyl 1,2,3‐triazole‐4,5‐dicarboxylate allowed synthesis of the isomeric 1‐methyl‐4,7‐dihydr