✦ LIBER ✦
Synthesis of (−)-noranisatin, an oxidation product of a neurotoxic sesquiterpenoid anisatin having a novel spiro β-lactone
✍ Scribed by Haruki Niwa; Shigeki Ito; Takashi Hasegawa; Kazumasa Wakamatsu; Tatsuya Mori; Kiyoyuki Yamada
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 128 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The synthesis of (-)-noranisatin (2), an oxidation product of anisatin (1) possessing a novel Spiro P-lactone,was achieved starting from trio1 5 prepared from (R)-(+)-pulegone (3).
Anisatin (1) is a neurotoxic sesquiterpenoid isolated from the seeds of Japanese star anise (Illicium anisurum L., shikimi in Japanese). l.2 The structure of anisatin (1) was elucidated by extensive chemical and spectroscopic studies. Noranisatin (2), an oxidation product of anisatin (l), played an important role in the structural determination.2