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Synthesis of Nor- C -linked Neuraminic Acid Disaccharide: A Versatile Precursor of C -Analogs of Oligosialic Acids and Gangliosides

✍ Scribed by Yuan, Xuejun; Ress, Dino K.; Linhardt, Robert J.


Book ID
126161758
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
122 KB
Volume
72
Category
Article
ISSN
0022-3263

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The 9-amino or 9-N-acyl-5-trifluoroacetyl methyl alpha-ketosides (1a-c) and their 2,3-didehydro analogs (2a-c) have been synthesized through Neu5Ac aldolase-catalyzed aldol reaction of 6-azido-2-benzyloxycarbonylamino-2-deoxy-D-mannose with sodium pyruvate. The six compounds were investigated as inh