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Synthesis of nona-deutero olivetol and nona-deutero cannabinoids

✍ Scribed by Herbert H. Seltzman; Mosammat K. Begum; Christopher D. Wyrick

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
387 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Copper (I) catalyzed Grignard cross coupling of alkyl bromides provided a facile synthesis of d~9~‐olivetol [5‐(2,2,3,3,4,4,5,5,5‐^2^H~9~)pentyl‐1,3‐benzenediol] with high d~9~ incorporation levels and no detectable levels of d~0~ to d~7~ ions. The outcome of the coupling is dependent on which bromide is used as the Grignard reagent. d~9~‐Δ^9^‐THC and racemic d~9~‐11‐hydroxy‐Δ^9^‐THC suitable for GC/MS analysis were prepared from the olivetol.

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