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Synthesis of Non-Nucleosides: 7- and 1,3-Substituents of New Pyrrolo[2,3-d]pyrimidin-4-ones on Antiviral Activity

✍ Scribed by Khalid Mohammed Hassan Hilmy

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
516 KB
Volume
339
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

A series of non‐nucleosides 9–47 were synthesized. Compounds 1–4 were reacted with formic acid (85%) to afford compounds 5‐8. Then, the latter compounds were reacted with alkyl halides a–f (2‐bromopropane, 2‐bromobutane, benzyl bromide, benzyl chloromethyl ether, chloromethyl ethyl ether, phenacyl bromide) in the presence of NaH in dry DMF to give the desired compounds 9–47, which were evaluated for activity against herpes simplex virus type‐II (HSV‐II).

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