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Synthesis of Non-Natural Aromatic α-Amino Acids by a Heck Reaction

✍ Scribed by Marcel Suhartono; Markus Weidlich; Torsten Stein; Michael Karas; Gerd Dürner; Michael W. Göbel


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
222 KB
Volume
2008
Category
Article
ISSN
1434-193X

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We present two complementary methods for the stereoselective synthesis of non-natural alpha-amino acids with aromatic or heteroaromatic side chains. One approach is based on the chemical transformation of methionine, whereas the other applies the stereoselective Myers alkylation of glycine. The resu