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Synthesis of New Triazolo[4',5':2,3]-triazino[5,6-b]quinoxalines

✍ Scribed by Μoustafa, O.S.; Badr, M.Z.A.

Book ID: 124065505
Publisher: Walter de Gruyter GmbH & Co. KG
Year: 1997
Tongue: English
Weight: 332 KB
Volume: 3
Category: Article
ISSN: 0793-0283
DOI: 10.1515/HC.1997.3.5.465

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✦ Synopsis

Reaction of triazino[5,6-b]-3(4H)-quinoxalin one 2 with and/or pocl3 gave triazinoquinoxalin-3-thione 3 and/or the corresponding 3-chloro derivative 7. Treatment of 3 with alkvl (aralkyl) halides gave the corresponding 3-thioalkyl substituentes 4. Treatment of either 3 or 7 with hydrazine hydrate gaves the 2-hvdrazino derivative 8. Reaction of 3 with ethyl chloroacetate gave thioester ϊ which on treatment with hydrazine hydrate gave the corresponding thiocarbohydrazide derivative 6. Hydrazino derivative 8 was utilized as versatil to produce several of fused heterocyclic through ring closure reactions with chloroacetylchloride, ethyl chloroformate, carbon disulfide, benzoyl chloride, formic acid and/or nitrous acid to give substituted triazoIo[4,3-b]triazinoquinoxaline(9-12,15) and/or tetrazo!o[4,5-b]triazinoquinoxaline 13.

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