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Synthesis of new thiazolo[2,3-b]pyrimidine derivatives of pharmaceutical interest

✍ Scribed by H. H. Abdel-Razik

Book ID
111490972
Publisher
Versita
Year
2006
Tongue
English
Weight
187 KB
Volume
60
Category
Article
ISSN
0366-6352

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✦ Synopsis

Abstract

2H-5-Amino-6-cyano-3,7-dioxothiazolo[2,3-b]pyrimidine was subjected to ring formation affording thiazolo[2,3-b]pyrimidine derivatives. 2H-5-Amino-6-cyano-3,7-dioxo-2-phenylmethylenethiazolo[2,3-b]pyrimidine was also subjected to ring formation affording pyrimido[4,5-d]-, pyrano[2,3-d]-, and pyrido[2,3-d]thiazolo[2,3-b]pyrimidine derivatives. 2-Anilinothiocarbonyl-3,9-dioxo-8-imino-7-phenyl-6-thioxothiazolo[2,3-b]pyrimido[4,5-d]pyrimidine and 8-amino-3,9-dioxo-6-thioxothiazolo[2,3-b]pyrimido[4,5-d]pyrimidine reacted with Ξ±-haloactive-methylene compounds to afford heterocyclic compounds containing two, fused and isolated, thiazole moieties, respectively.

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A.R. Egypt Eingegangen am 30. Man 1982 The new 5H-thiazolo[4,3-b]quinazoline-3,5(lH)-diones 3, ~II-C, 5a-c and 5H-thiazolo[2,3-b]quinazoline-3,5(2H)-diones 9ac, 11were prepared by reaction of anthranilic acid with the 2-thiazolidinone-4-thione derivatives lb, h, 7a-c and the 5-substituted 2-(alkylme