Synthesis of new side-chain polyrotaxanes via free radical polymerization of a water-soluble semi-rotaxane monomer consisting of 2,6-dimethyl-β-cyclodextrin and 3-O-(11-acryloylaminoundecanoyl)cholic acid
✍ Scribed by Olaf Noll; Helmut Ritter
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 351 KB
- Volume
- 199
- Category
- Article
- ISSN
- 1022-1352
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✦ Synopsis
The synthesis of a new water-soluble semi-rotaxane monomer consisting of threaded 2,6-dimethyl-P-cyclodextrin on a 3-O-( 11 -acryloylaminoundecanoyl)cholic acid guest component is described. This new monomer complex was polymerized in water as a solvent in the presence of a free radical redox initiator, yielding a side-chain polyrotaxane. Two main fractions of the resulting polymeric product were isolated by extraction with water. About 50 wt.-% of the polymer material contains approximately 40 mol-'% of noncovalently anchored cyclodextrin with regard to the amount of side-chain units. This fraction is not soluble in water. Additionally, a smaller water-soluble fraction with a significantly lower degree of polymerization was isolated bearing nearly one cyclodextrin on each side-chain unit.