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Synthesis of New Seven-Membered Ring Cyclic Dipeptides From Functionalized β-Amino Acids

✍ Scribed by Ouafâa El Mahdi; Jean-Pierre Lavergne; Jean Martinez; Philippe Viallefont; E. M. Essassi; C. Riche

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 273 KB
Volume: 2000
Category: Article
ISSN: 1434-193X
DOI: 10.1002/(sici)1099-0690(200001)2000:2<251::aid-ejoc251>3.0.co;2-e

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✦ Synopsis

A short synthesis of new, functionalized seven-membered removed and the cyclization took place diastereoselectively in the presence of the coupling agent BOP. Amide ring cyclic dipeptides is described. After the coupling of Nprotected β-amino acids to N-substituted α-amino tert-butyl substitution was found to be effective in promoting the cyclization of linear dipeptides. esters, the protective groups of the terminal functions were also recognize this substitution effect in performing small- [a] Laboratoire des Amino acides, Peptides et Prote ´ines, vent the competitive formation of an intramolecular cycli-

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