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Synthesis of new ribosylated Asn building blocks as useful tools for glycopeptide and glycoprotein synthesis

✍ Scribed by M. Angeles Bonache; Francesca Nuti; Alexandra Le Chevalier Isaad; Feliciana Real-Fernández; Mario Chelli; Paolo Rovero; Anna M. Papini

Book ID
104096585
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
326 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

We performed the first synthesis of new Asn derivatives bearing aor b-ribose as pure anomers, linked by an N-glycosidic bond, on the side chain of the Asn residue orthogonally protected for Fmoc/ t Bu SPPS, by an efficient five-step strategy with a global yield of 73% starting from D-ribose. These building blocks are obtained in a large scale and can be useful tools for glycopeptide and glycoproteins synthesis.

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