Synthesis of new pyrrolidine C-nucleosides via Staudinger-aza-Wittig cyclization of γ-azido ketone

✍ Scribed by Dong Chan Kim; Kyung Ho Yoo; Dong Jin Kim; Bong Young Chung; Sang Woo Park

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 249 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00854-0

✦ Synopsis

Novel N-acetyl C-aza-2-deoxy-D-ribonucleosides were synthesized from 2-deoxy-D-ribose via a consecutive procedure of the addition of ortho-lithiated pyrimidine salt, Staudinger-aza-Wittig ring cyclization, and reduction of cyclic imine.