Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain
β Scribed by Hiroshi Nagase; Junko Akiyama; Ryo Nakajima; Shigeto Hirayama; Toru Nemoto; Hiroaki Gouda; Shuichi Hirono; Hideaki Fujii
- Book ID
- 113496742
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 596 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0960-894X
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## Abstract Coupling of various acylated amino acid derivatives with (naphthalenβ2βlyloxy)acetic acid (**3**) in the presence of 1βhydroxyβbenzoteriazole (HOBt) and DCC afforded the new amides **6β12**. Alternatively, the latter compounds were prepared from reaction of the corresponding hydrazide *
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