Synthesis of New Nucleosides by Coupling of Chloropurines with 2-and 3-Deoxy Derivatives of N-Methyl-D-ribofuranuronamide. -Coupling of (II), obtained from commercially available 2-deoxy-D-ribose, with the chloropurine (I) affords regioselectively the nucleosides (III), whereas the β-methoxy analog
Synthesis of New Nucleosides by coupling of chloropurines with 2- and 3-deoxy derivatives of N-methyl-D-ribofuranuronamide
✍ Scribed by Rosaria Volpini; Emidio Camaioni; Sauro Vittori; Luciano Barboni; Catia Lambertucci; Gloria Cristalli
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- German
- Weight
- 478 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0018-019X
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## Abstract Convergent syntheses of the 9‐(3‐X‐2,3‐dideoxy‐2‐fluoro‐__β__‐D‐ribofuranosyl)adenines **5** (X=N~3~) and **7** (X=NH~2~), as well as of their respective __α__‐anomers **6** and **8**, are described, using methyl 2‐azido‐5‐__O__‐benzoyl‐2,3‐dideoxy‐2‐fluoro‐__β__‐D‐ribofuranoside (**4**
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