## Abstract The reaction of aldimines with __α__‐(hydroxyimino) ketones of type **10** (1,2‐diketone monooximes) was used to prepare 2‐unsubstituted imidazole 3‐oxides **11** bearing an alkanol chain at N(1) (__Scheme 2, Table 1__). These products were transformed into the corresponding 2__H__‐imid
Synthesis of new imidazole derivatives
✍ Scribed by Krystyna Nowak; Barbara Szpakiewicz
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2008
- Tongue
- English
- Weight
- 240 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
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The derivatives of 1‐propyl‐ and 1‐butyl‐ of 2‐methyl‐5‐nitroimidazole containing phenylpiperazine, m‐chloro‐ and o‐methoxyphenylpiperazine attached at the end of alkyl chain were synthesed. For the obtained new compounds, the biological activity was predicted using the computer program PASS.
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## Abstract 1‐Arylalkyl‐5‐phenylsulfonamino‐imidazole‐4‐carboxylic acid esters and their carboxamides with an additional secondary amino group were synthesized and identified as antiplatelet agents in a low micromolar range (Born‐test, inducer collagen). To describe the mechanism of action more pre