Synthesis of new heterocycles containing more than one 1,2,3-thia or selenadiazole rings

✍ Scribed by Mousa Al-Smadi

• Book ID: 102339270
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2007
• Tongue: English
• Weight: 254 KB
• Volume: 44
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570440427

✦ Synopsis

Abstract

magnified image

The diketones 2a‐d with different alkyl chain length are used for the synthesis of di‐1,2,3‐thia or selenadiazole derivatives 4a‐d and 5a‐d. The diketones 2a‐d where prepared by a unique method through the reaction between the corresponding dibromoalkanes 1a‐d and ethyl acetoacetate, which are transformed into the corresponding semicarbazone derivatives 3a‐d. The di‐1,2,3‐thia or selenadiazole derivatives 4a‐d and 5a‐d were prepared from the semicarbazones derivatives 3a‐d on oxidative cyclization with thionyl chloride and selenium dioxide respectively in high yield.