Synthesis of new enzymatically degradable thermo-responsive nanogels
✍ Scribed by Aguirre, Garbiñe ;Ramos, Jose ;Forcada, Jacqueline
- Book ID
- 118041020
- Publisher
- Royal Society of Chemistry
- Year
- 2013
- Tongue
- English
- Weight
- 865 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1744-683X
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## Abstract Biodegradable hydrogels were synthesized by the click reaction of 4‐arm azido‐terminated PEG differing in molecular weight (2 100 and 8 800) and two alkyne‐terminated peptides: [alkyne]‐GFLGK‐[alkyne] and ([alkyne]‐GFLG)~2~K. The physical properties of in situ formed hydrogels were exam
Several enzymes immobilized on thermoresponsive polyacrylamide polymers are nearly as active as their soluble forms, and can be recovered for reuse after gentle heating and precipitation. Carbohydrates attached to these polymers have been used for enzymatic glycosylation, and the products have been