Synthesis of new condensed and cyclized coumarin derivatives
✍ Scribed by S. V. Dekić; V. S. Dekić; B. R. Dekić; M. S. Dekić
- Book ID
- 111491052
- Publisher
- Versita
- Year
- 2007
- Tongue
- English
- Weight
- 217 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0366-6352
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✦ Synopsis
Abstract
Condensation of 4-chloro-2-oxo-2H-chromene-3-carbonitrile with selected heteroarylamines in acetonitrile containing a catalytic amount of triethylamine, followed by intramolecular cyclization, gave the new coumarin derivatives with yields ranging from 43 % to 78 %. The novel compounds were subjected to acid hydrolysis giving the corresponding oxo derivatives in 66–70 % yield. The structural assignments of the synthesized compounds were based on elemental, IR, 1H and 13C NMR analyses.
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