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Synthesis of new condensed and cyclized coumarin derivatives

✍ Scribed by S. V. Dekić; V. S. Dekić; B. R. Dekić; M. S. Dekić


Book ID
111491052
Publisher
Versita
Year
2007
Tongue
English
Weight
217 KB
Volume
61
Category
Article
ISSN
0366-6352

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✦ Synopsis


Abstract

Condensation of 4-chloro-2-oxo-2H-chromene-3-carbonitrile with selected heteroarylamines in acetonitrile containing a catalytic amount of triethylamine, followed by intramolecular cyclization, gave the new coumarin derivatives with yields ranging from 43 % to 78 %. The novel compounds were subjected to acid hydrolysis giving the corresponding oxo derivatives in 66–70 % yield. The structural assignments of the synthesized compounds were based on elemental, IR, 1H and 13C NMR analyses.


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