Synthesis of new chiral phosphinephosphites having 2-diphenylphosphinobiphenyl-2′-yl backbone and their use in Rh(I)-catalyzed asymmetric hydroformylations

✍ Scribed by Takanori Higashizima; Nozomu Sakai; Kyoko Nozaki; Hidemasa Takaya

• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 301 KB
• Volume: 35
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)73039-5

✦ Synopsis

New cbw ~~ VP~S~~ch~*4,~-~y~y~~yt)({s)-l,l'-bi~~~-2,~~yl}p~~bi~ [abbreviated (R,S)-BIPHEhWHOS) and its mantiomer (sJt)-BWHEMPHOS have barn synthesized Cum SS'-dichbro4,4'~,6'-~~y~-2~-~~y~oi in cnanpm form. Their Rh(I) complexes have been shown 10 be highly efficient catalysts for asymmetric hydmfamylations of a variaty of olefinic substrams. The mng wtes derived from 2,2'biphcayknol wae aim tested as ligsxds far asymmetric hydrofmylution. Recently we have mported that the Rh(I) complexes of phosphinephosphite ligand (R,Q-1 and its enantiomer (SP)-1 are highly efficient catalysts for enantioselective hydroformylation of a variety of mono and 1,2disubstituted olefins. '2 In these ligands atropisomeric l.l'-binaphthalene moieties are used as chkal elements.