✦ LIBER ✦

Synthesis of New Annellated Flavonoid Derivatives Possessing Spasmolytic Activity - VII

✍ Scribed by Rahmiye Ertan; Hakan Göker; Mevlüt Ertan; Ulf Pindur

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 279 KB
Volume: 322
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.19893220409

No coin nor oath required. For personal study only.

✦ Synopsis

7.8-Dihydroxyflavone reacts with ethyl 2,3-dibromopropanoate to form the new, annellated. 1.4-benzodioxanes 1 containing a flavone saUcturd unit Synthese neuer anellierter Flavonoid-Derivate mit spasmolytischer Akt i v i d , 7. Mitt. The regioisomers la and lb thus obtained were separated and la was converted to the amides 2a-2f. The constitutions of 1 and 2 were elucidated by 500 MHz IH-NMR spectroscopy. In the spasmolysis test, 2e showed significant antagonistic effects towards the agonists acetylcholine, barium chloride, and histamine.

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