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Synthesis of new 6-Aroylpyrido[2,3-d]pyrimidines

✍ Scribed by Jairo Quiroga; GermÁN Viveros; Braulio Insuasty; Manuel Nogueras; Adolfo Sánchez; Justo Cobo

Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
253 KB
Volume
36
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The synthesis of 6‐dimethylaminomethylenaminopyrimidin‐4(3__H__)‐ones 2 and its reaction with β‐dimethyl‐aminopropiophenone hydrochloride 3 is discussed in this work. The reaction of 6‐aminopyrimidin‐4(3__H__)‐ones 1 with an excess of dimethylformamide dimethyl acetal gives rise to the formation of 6‐dimethylaminomethyleneaminopyrimidines 2. The heating of equimolecular quantities of 2 and 3 in dimethylformamide leads to the 6‐aroylpyrido[2,3‐d]pyrimidines derivatives 4. The structures of compounds 2 and 4 were determined on the basis of nmr measurements.

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