Synthesis of new 5-substitutedbenzo[b]thiophene derivatives

✍ Scribed by S. Pérez-Silanes; J. Martínez-Esparza; A. M. Oficialdegui; H. Villanueva; L. Orúas; A. Monge

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2001
• Tongue: English
• Weight: 61 KB
• Volume: 38
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570380502

✦ Synopsis

Abstract

Previous works of our group have dealt with the synthesis of 1‐(aryl)‐3‐[4‐(aryl)piperazin‐1‐yl]propane derivatives in the search for new and efficient antidepressants with a dual mode of action: serotonin reuptake inhibition and 5‐HT~1A~ receptor afinity [1‐4]. From these studies we concluded that the 3‐[4‐(aryl)piperazin‐1‐yl]‐1‐(benzo[b]thiophen‐3‐yl)propane derivatives led to the best results. The continuation of this research project required the preparation of some new 3‐acyl‐5‐substituted benzo[b]thiophenes with a wide variety of substituents at the 5 position, ranging from nitro to hydroxyl derivatives. To obtain these derivatives we acylated the corresponding 5‐substituted benzo[b]thiophenes when it was possible.