## Abstract For Abstract see ChemInform Abstract in Full Text.
Synthesis of New 5-Mercapto-1,3-oxazole Derivatives on the Basis of 2-Acylamino-3,3-dichloroacrylonitriles and Their Analogs
✍ Scribed by S. G. Pil'o; V. S. Brovarets; T. K. Vinogradova; A. V. Golovchenko; B. S. Drach
- Book ID
- 110435199
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 88 KB
- Volume
- 72
- Category
- Article
- ISSN
- 1070-3632
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📜 SIMILAR VOLUMES
## Abstract Available 2‐acylamino‐3,3‐dichloroacrylonitriles, when treated with hydrazine hydrate, provide 2‐alkyl‐ or 2‐aryl‐5‐hydrazino‐1,3‐oxazole‐4‐carbonitriles that readily add alkyl or aryl isothiocyanates and the adducts formed recyclize on heating. Finally, the synthesis results in 5‐alkyl
## Abstract Readily accessible acylamino(chloro)acetophenones, if treated with sodium rhodanide and α‐halogenocarbonyl compounds, provide 4‐acylamino‐5‐aryl‐2‐mercapto‐1,3‐oxazole derivatives which undergo recyclization on heating in polyphosphoric acid to give substituted 1,3‐thiazol‐2(3__H__)‐one
Readily available 2-acylamino-3,3dichloroacrylonitriles are sequentially treated with methyl mercaptoacetate in the presence of sodium methylate and with sulfuric acid to furnish the methyl ester of 7-amino-2-oxo-3H-thieno [2,3-b][1,4]thiazine-6-carboxylic acid. Treating it first with triethyl ortho