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Synthesis of new 4-oxo-thiazolidine-5-ylidenes of antitumor and antioxidant activities

✍ Scribed by Ashraf A. Aly; Alan B. Brown; Mohamed Abdel-Aziz; Gamal El-Din A. A. Abuo-Rahma; Mohamed F. Radwan; Mohamed Ramadan; Amira M. Gamal-Eldeen

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
210 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image Reaction of diacyl thiocarbohydrazides with dimethyl but‐2‐ynedioate in refluxing ethanol led to 4‐oxa‐thiazolidine‐5‐ylidene‐acetates in good yields. Reaction of the newly prepared N‐(2‐(propan‐2‐ylidene) hydrazine‐carbonothioyl)arylhydrazides with dimethyl but‐2‐ynedioate gave the corresponding (Z)‐methyl‐2‐arylhydrazide‐4‐oxo‐3‐(propan‐2‐ylideneamino)thiazolidine‐5‐ylidene)‐acetates. The mechanism is discussed. Antitumor and antioxidant activities have been also investigated. J. Heterocyclic Chem., (2010).

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