Synthesis of new 2-substituted pyrido[2,3-d]pyrimidin-4(1H)-ones and their antibacterial activity
β Scribed by B. Lakshmi Narayana; A. Raghu Ram Rao; P. Shanthan Rao
- Book ID
- 108116166
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 262 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0223-5234
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Functionalized 2,3-Dihydrothieno[2,3-d ]pyrimidin-4(1H )ones and Their Recyclization to 2,3-Dihydrothieno[3,4-d ]pyrimidin-4(1H )-ones
## Abstract magnified image The thienopyridine derivative **2**, obtained from reaction of acetoacetic ester with **1** in the presence of tin tetrachloride, was treated with triphenylphosphine in hexachloroethane and Et~3~N to give iminophosphorane **3**. Iminophosphorane **3** reacted with pheny
## Abstract magnified image Carbodiimide, obtained from azaβWittig reaction of iminophosphorane with 4βfluorophenyl isocyanate, reacted with various nucleophiles under mild conditions to give a series of 2βsubstitutedβ3β(4βfluorophenyl)βbenzofuro [3,2βd] pyrimidinβ4(3H)βones in satisfactory yield.