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Synthesis of New 14-Membered Macrolide Antibiotics via a Novel Ring Contraction Metathesis

✍ Scribed by Lazarova, Tsvetelina I.; Binet, Sophie M.; Vo, Nha H.; Chen, Jason S.; Phan, Ly T.; Or, Yat Sun


Book ID
121204638
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
52 KB
Volume
5
Category
Article
ISSN
1523-7060

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## Abstract For the synthesis of a 12‐membered salicylic macrolide scaffold, ring‐closing metathesis (RCM) of a ω‐diene compound was planned. The stereochemical outcome of the RCM reaction changed depending on the type of Ru catalyst that was used; a β€œfirst‐generation” Grubbs catalyst produced excl