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Synthesis of new 1,1-dimethyl-1,2,3,4-tetrahydrophenanthrene derivatives

✍ Scribed by Xian-Zhang Bu; Zhi-Shu Huang; Min Zhang; Lin Ma; Gui-Wu Xiao; Lian-Quan Gu

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 82 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01034-6

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✦ Synopsis

Naturally occurring diterpenoid tanshinones have attracted particular attention from medicinal chemists and clinicians because many of them exhibit interesting physiological properties. 1 Cryptotanshinone 1, a typical diterpenoid tanshinone from Salvia miltiorrhiza Bunge, was found to exhibit enzyme inhibitory activities. 2 Tanshinone 1 is characterised by the presence of a dihydrofuran ring and an o-quinone moiety, which are able to react with nucleophilic agents. In this paper, we report the interaction of cryptotanshinone with NH 3 , CH 3 NH 2 and C 2 H 5 NH 2 (Scheme 1), which may afford more direct evidence for the mechanism of the inhibitory activity of tanshinones with various enzymes.

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