## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Synthesis of neoglycolipids for the development of non-viral gene delivery systems
✍ Scribed by E. V. Shmendel’; M. A. Maslov; N. G. Morozova; G. A. Serebrennikova
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 324 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1573-9171
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Delivering genes to mediate functions of cells is a crucial technology for both basic science and clinical applications. Though numerous non-viral gene delivery systems have been developed, the diversity of mammalian cells poses a great challenge to the material design. Here, we demonstrate that sur
Calcium phosphate (CaP) based approaches remain an attractive option for delivering plasmid DNA (pDNA) into cultured cells. However, despite their appeal, current synthesis methodologies typically yield lower, less consistent transfection efficiencies when compared to viral approaches. Therefore, we
## Abstract Review: 31 refs.
## Abstract ## Background The immunogenicity of viral DNA vectors is an important problem for gene therapy. The use of peptide motifs for gene delivery would largely overcome this problem, and provide a simple, safe and powerful approach for non‐viral gene therapy. ## Methods We explored the fun