Synthesis of natural-product-based compound libraries

✍ Scribed by Ludger A Wessjohann

• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 198 KB
• Volume: 4
• Category: Article
• ISSN: 1367-5931
• DOI: 10.1016/s1367-5931(00)00093-4

✦ Synopsis

Natural products cover a diversity space not yet available from synthetic libraries, with an unrivalled success rate as drug leads. The combinatorial synthesis of non-oligomeric natural-product-based libraries, however, is still limited to few examples because access to easily modified units strongly depends on the availability of a core structure either from a natural source, or through a suitable synthetic route. Only a few resourceful groups have managed the latter approach for more demanding multifunctional natural drug leads, such as epothilones.