N-Thioacylation of ฮฒ-Amino Alcohols by N
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Christopher T Brain; Allan Hallett; Soo Y Ko
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Article
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1998
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Elsevier Science
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French
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~arnino alcohols are selectivelyN-thioscylatedby N-(thioacyl)phthalimidesunder very mild conditions to provide N-(hydroxyethyl)thiosmidesin high yields. CycMehydration with Burgess reagent then provides a-amino acid thiazolines. This approach provides a convenientattereative to those baaed upon rfri