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Synthesis of N-Substituted 2,4-Diaminothiazoles and Their Salts

โœ Scribed by Hartmann, Horst; Flaig, Ronald


Book ID
118173822
Publisher
Japan Institute of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
403 KB
Volume
45
Category
Article
ISSN
0385-5414

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Synthesis and Cyclization of 1-(N-Nitroamidino)thioureas to 2,4-Diaminothiazoles. -Reaction of nitroguanidine (I) with isothiocyanates in the presence of powdered KOH provides 1-(N-nitroamidino)thioureas (III) which react with phenacyl bromides to give unexpectedly 2,4-diaminothiazoles (V) in high