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Synthesis of N-protected N-methyl serine and threonine

✍ Scribed by Yue Luo; Ghotas Evindar; Dan Fishlock; Gilles A Lajoie

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 71 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00606-2

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✦ Synopsis

Two efficient and convenient syntheses of N-Cbz and N-Fmoc N-methyl serine and threonine are described. The amino acid side-chain alcohol can be protected as a TBDMS ether in very good yield or left free, followed by the formation and subsequent reduction of the corresponding oxazolidinone.

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