Synthesis of N-[35S]-sulpho-2-amino tricarballylate

✍ Scribed by Malcolm R. Brown; Ravi Shankar; John D. Sallis

• Book ID: 102371619
• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: French
• Weight: 243 KB
• Volume: 21
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580211004

✦ Synopsis

The synthesis of [ 'S]-labelled N-sulpho-2-amino tricarballylate (SAT) and methods f o r its purification and analysis are described. I n the first stage of the two-step synthesis, chloro-[ SS]-sulphonic acid is reacted with pyridine to yield pyridine-[ 35S]-sulphur trioxide. This agent is then utilized to sulphonate 2-amino tricarballylic acid yielding the ultimate product [ 'SI-SAT, which was required for pharmacokinetic studies.