✦ LIBER ✦
Synthesis of mucin-type glycopeptide (β hCG 130–145) by on-resin fragment condensation of the glycopeptide segments carrying unmasked oligosaccharides
✍ Scribed by Tsuyoshi Ichiyanagi; Maki Takatani; Kimitoshi Sakamoto; Yuko Nakahara; Yukishige Ito; Hironobu Hojo; Yoshiaki Nakahara
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 137 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Use of amino acid pentafluorophenyl esters was found effective for chemoselective N-acylation in the peptide elongation. On-resin fragment condensation between 9 and 13 using DCC-PfpOH as an activator afforded coupling product 1 in good yield.