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Synthesis of Modified RNA-Oligonucleotides for Structural Investigations

✍ Scribed by A. Zivkovic; J. W. Engels


Publisher
John Wiley and Sons
Year
2004
Weight
59 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract We describe the synthesis and binding properties of oligonucleotides that contain one or more 2′‐fluoro‐α‐L‐RNA thymine monomer(s). Incorporation of 2′‐fluoro‐α‐L‐RNA thymine into oligodeoxynucleotides decreased thermal binding stability slightly upon hybridization with complementary DN