Synthesis of Mixed ( E , Z )-, ( E )-, and ( Z )-Norendoxifen with Dual Aromatase Inhibitory and Estrogen Receptor Modulatory Activities
โ Scribed by Lv, Wei; Liu, Jinzhong; Lu, Deshun; Flockhart, David A.; Cushman, Mark
- Book ID
- 120390161
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 878 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
## E-and Z-enynes available by stereoselective dehydrations of Co2(CO) complexed and uncomplexed propargyl alcohols 13 and 5 produced acetylenic LT-E4 analogs with !! ontractile activity similar to leukotrienec Their 5-desoxy analogs were found to have antagonist activity against LT-C4 induced con
A selective exchange reaction of the symmetrical acetal 3 with protected cysteine readily provided the hemi-thioacetals 9,a and lla related to leukotrlene-E . Use of acetylene- bis-(diethyl acetal) 12 led to a facile synth&is of the title compound 1 4 a. Its corresponding hexahydt? analogs displayed