Synthesis of mixed-donor azaoxathia macrocyclic tetraamides, acyclic polyether di/and tetraamides and their C-pivot lariat derivatives
✍ Scribed by Ashraf A. Abbas
- Book ID
- 102892924
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 630 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
magnified image
The macrocyclic tetraamides 11a‐e and 15‐hydroxy macrocyclic tetraamides 23a‐c were prepared in good yields by the nucleophilic reaction of the potassium salts of the bis‐phenoles 10a‐c with the appropriate dihalo compounds 5a‐d and 15. Moreover, the acyclic diamides 7, 9, 17‐21 and bis‐acyclic tetraamide 22 were obtained in high yields by the reaction of the appropriate dichloro compounds with different phenoxides and secondary amines. Acylation of 23a‐c with different acid chlorides gave the corresponding esters 24a‐c. Compounds 24a‐c reacted with different secondary amines to afford the corresponding novel lariat macrocycles 25a‐d in high yields.