Synthesis of (±)-mispyric acid, a triterpene inhibitor of DNA polymerase β isolated from Mischocarpus pyriformis

✍ Scribed by Yusuke Imamura; Hirosato Takikawa; Kenji Mori

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 94 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01193-0

✦ Synopsis

The first synthesis of (±)-mispyric acid, an inhibitor of DNA polymerase b with a novel triterpene skeleton, was achieved by starting from isoprene, geraniol and 1,5-dimethoxy-1,4-cyclohexadiene.